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About

Reduces post-acne marks and blemishes and prevents their reappearance. Controls shine and delivers a long lasting matte finish. First visible results in 2 weeks and continuous improvement over time
NART: 66862-09900-01

Eucerin DermoPure Triple Effect Serum with patented Thiamidol

Acne is a fact of life for a huge cross-section of society. It affects up to 95% of adolescents and 40% of adults*. Many people experience post-acne marks (Post-inflammatory hyperpigmentation or PIH for short) long after the acute acne has vanished. After tackling blemishes, they are still stuck fighting their post-acne marks, which can persist for several years or even a decade** with the sun aggravating the symptoms.

About 1 in 2 people experience post-acne marks. Men and women are equally susceptible, and all skin types can get post-acne marks, although it is more prevalent in darker tones of skin***.

Eucerin DermoPure Triple Effect Serum with patented Thiamidol enables you to finally beat blemishes and post-acne marks with 3 key factors:

  1. Anti-marks: Patented Thiamidol acts at the root cause of hyperpigmentation to reduce persistent post-acne marks and prevent their appearance.
  2. Anti-blemish: Salicylic Acid effectively reduces blemishes and Licochalcone A helps to prevent new blemishes from appearing.
  3. Anti-shine: Sebum Regulating Technology delivers a long-lasting dry, matt finish.

The Triple Effect Serum has enhanced efficacy when used together with the Eucerin DermoPure Protective Fluid SPF 30. In fact, respondents in our studies report that the products not only improved their lives and provided relief, but also have the highest efficacy against post-acne marks of any products they have ever tried. “The combination beats post-acne marks,” say 95% of users****.

* Zouboulis, C. C., Hautarzt. 2014; 65(8):733–750.

** Abad-Casintahan, F. et al., “Frequency and Characteristics of Acne-Related Post-Inflammatory Hyperpigmentation.” J Dermatol. 2016; 43:826–828.

*** Kaufman et al., Am J Clin Dermatol. 2018; 19:489–503, Perkins et al., JEADV. 2011; 25(9):1054–1060.

**** Product in use study with 100 volunteers, 8 weeks of regular usage twice a day of both Serum and Fluid SPF 30.

Main findings

Among other clinical and dermatological studies, a Product in Use (PIU) study was conducted, with 100 volunteers over 8 weeks of regular use twice a day.
-66%
PIMPLES 1
-80%
ACNE MARKS 2
-62%
COMEDONES 3
97%
FEEL MORE CONFIDENT ABOUT THEIR SKIN 4

Clinical Formula

Thiamidol

Thiamidol is a patented ingredient, known to fight hyperpigmentation acting at its root cause. It works by inhibiting the human tyrosinase, the key enzyme in melanin production. Hyperpigmentation can be the result of different causes, e.g. sun-induced pigment spots, post-acne marks or age spots. Key benefits are:

  • Reduction of Hyperpigmentation: By effectively inhibiting tyrosinase, Thiamidol decreases melanin synthesis, leading to a visible reduction in dark spots and an even skin tone.
  • Works on all skin types: Thiamidol is dermatologically tested and suitable for all skin types, including dry, oily, combination, normal and sensitive skin. It works for skin of any ethnicity or age and thus is effective on all skin types and tones.
  • Fights post-acne marks: Post-inflammatory hyperpigmentation happens when skin is inflamed or injured, for example because of acne. The impacted area is left darkened and hyperpigmented despite having otherwise healed. Thiamidol addresses these areas resulting in an even skin tone.
Learn More
Salicylic Acid

Salicylic Acid, a beta hydroxy acid (BHA) is a potent exfoliating and comedolytic agent that effectively targets blemish-prone skin by unclogging pores and reducing bacterial growth. Key benefits are:

  • Deep Pore Cleansing: As a small lipophilic molecule, Salicylic Acid penetrates deep into pores, dissolving excess sebum and dead skin cells to prevent clogging and breakouts.
  • Exfoliating & Smoothing Effect: Gently promotes the removal of dead skin cells, refining skin texture and improving overall clarity.
  • Anti-Bacterial Action: Effectively counteracts Cutibacterium acnes, a key bacteria responsible for acne development, helping to reduce existing blemishes and prevent future breakouts.
Learn More
Licochalcone A

Licochalcone A is a potent anti-inflammatory and antioxidant ingredient derived from the roots of the Chinese licorice plant (Glycyrrhiza inflata). Licochalcone A protects skin cells from oxidative stress and environmental aggressors like UV and blue light (HEVIS). Key benefits are:

  • Antioxidant Defense: Activates antioxidant and detoxifying enzymes, shielding skin cells from oxidative damage, including lipid peroxidation, DNA- and protein damage.
  • Anti-Inflammatory Action: Effectively reduces redness and soothes irritated skin, making it ideal for sensitive and irritated and stressed skin conditions.
Learn More
Thiamidol

Thiamidol is a patented ingredient, known to fight hyperpigmentation acting at its root cause. It works by inhibiting the human tyrosinase, the key enzyme in melanin production. Hyperpigmentation can be the result of different causes, e.g. sun-induced pigment spots, post-acne marks or age spots. Key benefits are:

  • Reduction of Hyperpigmentation: By effectively inhibiting tyrosinase, Thiamidol decreases melanin synthesis, leading to a visible reduction in dark spots and an even skin tone.
  • Works on all skin types: Thiamidol is dermatologically tested and suitable for all skin types, including dry, oily, combination, normal and sensitive skin. It works for skin of any ethnicity or age and thus is effective on all skin types and tones.
  • Fights post-acne marks: Post-inflammatory hyperpigmentation happens when skin is inflamed or injured, for example because of acne. The impacted area is left darkened and hyperpigmented despite having otherwise healed. Thiamidol addresses these areas resulting in an even skin tone.
Learn More
Salicylic Acid

Salicylic Acid, a beta hydroxy acid (BHA) is a potent exfoliating and comedolytic agent that effectively targets blemish-prone skin by unclogging pores and reducing bacterial growth. Key benefits are:

  • Deep Pore Cleansing: As a small lipophilic molecule, Salicylic Acid penetrates deep into pores, dissolving excess sebum and dead skin cells to prevent clogging and breakouts.
  • Exfoliating & Smoothing Effect: Gently promotes the removal of dead skin cells, refining skin texture and improving overall clarity.
  • Anti-Bacterial Action: Effectively counteracts Cutibacterium acnes, a key bacteria responsible for acne development, helping to reduce existing blemishes and prevent future breakouts.
Learn More
Licochalcone A

Licochalcone A is a potent anti-inflammatory and antioxidant ingredient derived from the roots of the Chinese licorice plant (Glycyrrhiza inflata). Licochalcone A protects skin cells from oxidative stress and environmental aggressors like UV and blue light (HEVIS). Key benefits are:

  • Antioxidant Defense: Activates antioxidant and detoxifying enzymes, shielding skin cells from oxidative damage, including lipid peroxidation, DNA- and protein damage.
  • Anti-Inflammatory Action: Effectively reduces redness and soothes irritated skin, making it ideal for sensitive and irritated and stressed skin conditions.
Learn More
Thiamidol

Thiamidol is a patented ingredient, known to fight hyperpigmentation acting at its root cause. It works by inhibiting the human tyrosinase, the key enzyme in melanin production. Hyperpigmentation can be the result of different causes, e.g. sun-induced pigment spots, post-acne marks or age spots. Key benefits are:

  • Reduction of Hyperpigmentation: By effectively inhibiting tyrosinase, Thiamidol decreases melanin synthesis, leading to a visible reduction in dark spots and an even skin tone.
  • Works on all skin types: Thiamidol is dermatologically tested and suitable for all skin types, including dry, oily, combination, normal and sensitive skin. It works for skin of any ethnicity or age and thus is effective on all skin types and tones.
  • Fights post-acne marks: Post-inflammatory hyperpigmentation happens when skin is inflamed or injured, for example because of acne. The impacted area is left darkened and hyperpigmented despite having otherwise healed. Thiamidol addresses these areas resulting in an even skin tone.
Learn More
Salicylic Acid

Salicylic Acid, a beta hydroxy acid (BHA) is a potent exfoliating and comedolytic agent that effectively targets blemish-prone skin by unclogging pores and reducing bacterial growth. Key benefits are:

  • Deep Pore Cleansing: As a small lipophilic molecule, Salicylic Acid penetrates deep into pores, dissolving excess sebum and dead skin cells to prevent clogging and breakouts.
  • Exfoliating & Smoothing Effect: Gently promotes the removal of dead skin cells, refining skin texture and improving overall clarity.
  • Anti-Bacterial Action: Effectively counteracts Cutibacterium acnes, a key bacteria responsible for acne development, helping to reduce existing blemishes and prevent future breakouts.
Learn More
Licochalcone A

Licochalcone A is a potent anti-inflammatory and antioxidant ingredient derived from the roots of the Chinese licorice plant (Glycyrrhiza inflata). Licochalcone A protects skin cells from oxidative stress and environmental aggressors like UV and blue light (HEVIS). Key benefits are:

  • Antioxidant Defense: Activates antioxidant and detoxifying enzymes, shielding skin cells from oxidative damage, including lipid peroxidation, DNA- and protein damage.
  • Anti-Inflammatory Action: Effectively reduces redness and soothes irritated skin, making it ideal for sensitive and irritated and stressed skin conditions.
Learn More
View all
FAQ

What are post-acne marks (post-inflammatory hyperpigmentation or PIH for short)?

PIH is a type of hyperpigmentation of the skin that is mainly triggered by the way skin regenerates after inflammation. It can affect the face and body, typically especially UV-exposed areas, and appears as flat spots of hypercoloration. These range in color from pink to red, brown or black, depending on skin tone and the depth of hypercoloration. The root cause is increased melanin production, the pigment that defines the color of a person’s skin, which is stimulated by inflammatory factors. The blemish triggers melanocytes – the melanin-producing cells – to release excessive melanosomes (pigment granules). The excessive pigment granules darken and discolor the formerly stressed area. Once initial blemishes have subsided, spots of hypercoloration, so-called post-acne marks, can remain.

Additionally, sun exposure can aggravate PIH symptoms, darkening the affected patches and prolonging the time it takes for them to fade. Most acne-related PIH will eventually fade over time, but it can take several years or even a decade until it is fully gone*.

*Abad-Casintahan, F. et al., “Frequency and Characteristics of Acne-Related Post-Inflammatory Hyperpigmentation.” J Dermatol. 2016; 43:826–828.

Who is affected by post-acne marks?

Post-inflammatory hyperpigmentation is common among many acne sufferers since a root cause for acne is inflammation. Those post-acne marks left behind after blemishes subsided can be even more aggravating and emotionally distressing than acne itself. Men and women are equally susceptible, and all skin types can get post-inflammatory hyperpigmentation, although it is more prevalent in darker tones of skin, with over 65% of the Black Americans experiencing it, followed by 53% of Hispanics, 47% of Asians and 25% of Caucasians*. This means that we need effective and tolerable skincare fighting both blemishes and post-inflammatory hyperpigmentation for consumers all over the world.

* Kaufman et al., Am J Clin Dermatol. 2018; 19:489–503, Perkins et al., JEADV. 2011; 25(9):1054–1060.

How can post-acne marks be prevented?

PIH is mainly triggered by the way skin regenerates after an inflammation. To prevent it, though there are no guarantees, avoid picking at or pressing your pimples. The best prevention is, however, to target acne-related PIH at the root, meaning preventing blemishes from appearing and getting inflamed. Use a mild but effective cleanser and use light, non-comedogenic skincare with anti-inflammatory ingredients, like licochalcone A and keratolytic salicylic acid, which are used in our Eucerin® Dermopure Triple Effect Serum to prevent pores from clogging. 

Additionally, sun exposure can aggravate PIH symptoms, so we recommend sun protection. Limit the time you spend in the sun and keep out of the sun during its most intense hours. Wear protective clothing and sun hats whenever possible and apply a sun protection factor of at least 30, to protect marks from darkening and help prevent new marks from appearing by using specialized skincare like Eucerin® Dermopure Protective Fluid SPF 30. 

What is so special about Thiamidol?

Thiamidol is an exclusive and patented active ingredient developed during a 10-year research project. It reduces post-inflammatory hyperpigmentation by addressing the root cause, the production of melanin in the skin. Many known ingredients have undergone testing on mushroom enzymes alone rather than on human skin enzymes. 
The efficacy of Thiamidol in our Eucerin® Dermopure Triple Effect Serum has been demonstrated in real-life testing. Clinical trials* and other responses have shown that our formulation effectively reduces post-acne marks.

*Clinical efficacy study, 12 weeks, 2× daily use, 40 female and male patients, 18–40 years of age.

Beyond Thiamidol, what makes the DermoPure Triple Effect Serum so effective on blemish-prone skin with post-acne marks?

In addition to Thiamidol to reduce persistent post-acne marks and prevent their appearance, it contains salicylic acid to reduce blemishes as well as licochalcone A to prevent new blemishes from appearing. Thanks to the sebum regulation technology, the formulation leaves the skin with a long-lasting, matte and non-shiny look. In addition, the serum is non-comedogenic and has a decidedly light feel on application.

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1 Real-world-evidence study, skin care regimen containing a cleansing gel, Triple Effect Serum and an SPF 30 day care, lesion count, n=427, 12 weeks of use twice daily, compared to baseline.

2 Clinical study, self-grading score, 43 volunteers, 12 weeks of use twice daily, compared to baseline.

3 Real-world-evidence study, skin care regimen containing a cleansing gel, Triple Effect Serum and an SPF 30 day care, lesion count, n=399, 12 weeks of use twice daily, compared to baseline.

4 Product-in-use, 100 subjects, after 4 weeks

New
DermoPure Clinical

DERMOPURE Triple Effect Serum

Skin concerns
Acne Prone Skin
Key Benefits
  • Anti-marks: Reduces persistent post-acne marks and prevents their appearance.
  • Anti-blemish: Effectively reduces blemishes and prevents new ones from appearing.
  • Anti-shine: Delivers a long-lasting, dry, matt finish.
  • 95% agree: Finally beats post-acne marks.
Read More
Key Ingredients

Thiamidol, Salicylic Acid, Licochalcone A

Learn More
Size
40 ml